ANTI-SCARRING
GENE THERAPY
ANTI-SCARRING EFFECT
OF LACTOFERRIN DERIVATE
Preclinical
Annals of Surgery. 250(6):1021-1028, 20
https://insights.ovid.com/pubmed?pmid=19953722
A Novel Polypeptide Derived From Human Lactoferrin in Sodium Hyaluronate Prevents Postsurgical Adhesion Formation in the Rat
Elin Nilsson; Camilla Björn; Veronika Sjöstrand; Kerstin Lindgren; Mattias Münnich; Inger Mattsby-Baltzer; Marie-Louise Ivarsson; Kjell Olmarker; Margit Mahlapuu
More than 50-70 percent reduction of scarring with formulations of lactoferrin derivate (PXL-01)
Gold standard multiple abrasion model in the rat
Clinical
PLOSOne 9(10) : e 110735 October 23, 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207831/pdf/pone.0110735.pdf
PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair
Surgery: Randomized Controlled Trial
Monica E. Wiig , Lars B. Dahlin, Jan Fridén, Lars Hagberg, Sören E. Larsen, Kerstin Wiklund,
Margit Mahlapuu
In a large multi center study in 138 patients anti-scarring peptide PXL-01 (enserptide) caused 40-60 percent improvement of scarring related dysfunction after hand surgery with repair of raptured tendon .
Scarring and adhesions may reduce the mobility of fingers which compromises hand function and Activities of Daily Life